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Lecithin Organigels
LOs provide opportunities for
incorporation of a wide range of
substances with diverse
physicochemical characters.
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Being thermodynamically stable,
the structure integrity of LOs
is maintained for longer time
periods.
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LOs are moisture insensitive,
and being organic in character,
they also resist microbial
contamination.
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Being well balanced in
hydrophilic and lipophilic
character, they can efficiently
partition with the skin and
therefore enhance the skin
penetration and transport of the
molecules
LOs also provide the desired
hydration of skin in a
lipid-enriched environment so as
to maintain the bioactive state
of skin.
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Use of biocompatible,
biodegradable and nonimmunogenic
materials makes them safe for
long-term applications.
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Amitriptyline
A 1998 review of 86 randomized,
controlled trials of
nonsteroidal anti-inflammatory
drugs with pain as an outcome
indicated that topical
nonsteroidals are significantly
more effecious than placebo for
pain relief.
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Amitriptyline is a tricyclic
antidepressant with clinically
proven efficiency in several
pain conditions. It has the
ability to antagonize sodium
channels, which may explain its
local anesthetic effect.
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Gabapentin
Gabapentin is an anticonvulsant
medication that has been studied
as a treatment for diabetic
neuropathy and post-herpetic
neuralgia.
Gabapentin monotherapy appears
to be efficacious for the
treatment of pain and sleep
interference associated with
diabetic peripheral neuropathy
and exhibits positive effects on
mood and quality of life.
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