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The information contained herein
is to be used for educational
purposes only. The author is not
a medical professional, and this
information should not be
considered medical advice. This
information should NOT be used
to replace consultation with or
treatment by a trained medical
professional.
In todays market, there is an
abundance of pain-relieving and
pain-killing medications
available for anyone to use. The
downside to these medications is
that they must be taken
systemically in high quantities
to provide local pain relief.
This systematic administration
disperses medication to the
target tissues achieving
therapeutic effect as well as
distributing to unwanted,
non-target organs. This most
often produces undesirable side-effects by accumulating in these
unwanted organs, such as nausea,
vomiting, dizziness and fatigue
or more serious complications
such as gastrointestinal injury
with nonsteriodal
anti-inflammatory agents (NSAIDs)
or nonselective prostaglandin
synthetase-cyclooxygenese (COX)
inhibitors. In most cases, pain
is localized in the body and the
treatment should theoretically
be focused on that particular
area. The primary issue is
finding a way to administer
proven drugs to localized pain
while minimizing side-effects.
A common way to provide
localized medications for pain
relief is through the use of
transdermal drugs as ointment,
creams, gels and lotions. The
main obstacle to local delivery
of drugs is the skin itself. The
skin is comprised of layers. The
epidermis, or top-most layer, is
the brick wall of the skin
layers. A number of studies have
shown that Pluronic lecithin
organogels (PLOs) have the
unique capacity to deliver drugs
across the epidermal barrier and
deliver particular medications
such as NSAIDs and local
anesthetics to specific tissue.
, PLO gel looks and feels like
a cream but is actually a gel.
Combining the aqueous phase (pluronic
gel) with the lecithin oil base
creates an emulsion that holds
together due to the surfactant
qualities of the pluronic gel
and the viscosity of that gel at
room temperature.
Topical vs. Oral
-
Less Overall Side Effects
-
No GI Discomfort or Distress
-
No Significant Systemic Side-Effects
-
Localized Pain and Inflammation Relief
-
Lower Dosages
-
Non-Addictive
-
Increased Patient Compliance
Topical vs. Patches
-
Patches usually only have single-active drug and few choices as
to strength and dosage.
-
Patients have more choices of
areas of application with a
cream.
-
Compounded creams can be
tailored to the patients
individual needs for the
strength and or dosage of any
component.
Why our creams are better than the rest.
Our Base is Pluronic Lecithin
Organogel
-
The PLO gel serves as a carrier
for the drug and "takes" it
across the skin.
-
One theory is that the PLO gel
slightly disorganizes the
structure of the skin, and thus,
permits the permeation of
various substances.
-
PLO gel looks and feels like a
cream but is actually a gel.
Combining the aqueous phase (pluronic
gel) with the lecithin oil base
creates an emulsion that holds
together due to the surfactant
qualities of the pluronic gel
and the viscosity of that gel at
room temperature.
The Pharmacists at Medi-Stat Rx
understand pain management and
the patient's concerns about
taking oral pain medications.
With Medi-Stat's topical pain
creams, all of those concerns
are eliminated. Each cream is
compounded by our pharmacists in
a sterile environment to the
exact needs of each and every
patient.
Pain Cream General Directions
-
Generally applied 2 to 4 times
daily.
-
The topical cream should be
rubbed in completely for at
least one minute.
-
May take 2 to 3 days for maximum
effect.
The cream has best results when
left on the treated area for 30
minutes to one hour.
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